Memory impairments in chronic fatigue syndrome patients

Abstract:

Background: Chronic Fatigue Syndrome (CFS) patients often report memory problems. Prior research has produced conflicting results on this topic. Episodic memory impairments appear to be robust, but tasks assessing other aspects of memory (e.g., working and semantic memory) show slower speed but no decrease in accuracy. This study examined whether the memory problems of CFS patients reflect slower responses. Methods: CFS patients were recruited from a specialist clinic. Sixty-seven patients carried out tasks measuring immediate recall, delayed recognition memory, logical reasoning and semantic processing. The control group were 126 healthy volunteers recruited from the general population.

Results: The CFS patients recalled fewer words and had poorer delayed recognition. The other tasks showed slower speed but no effect on accuracy.

Conclusions: CFS patients have poorer immediate recall and delayed recognition memory. The delayed recognition memory probably reflected the poorer immediate recall. Slower responding was present in three of the tasks, and it is possible that this also accounted for the reduced immediate recall.

Source:  Smith, Andrew. Memory impairments in chronic fatigue syndrome patients. wjpmr, 2022, 8(6), 50-54. ISSN 2455-3301 https://orca.cardiff.ac.uk/id/eprint/150176/1/article_1654063780_pub.pdf (Full text)

Behavioural problems associated with the chronic fatigue syndrome

Abstract:

Disturbances of memory, concentration and motor function are often reported by patients with the chronic fatigue syndrome (CFS). The present study objectively evaluated these behavioural problems using a computerized test battery measuring memory, attention and motor skills.

Fifty-seven CFS patients were compared with 19 matched controls and all subjects completed the performance test battery and filled in questionnaires measuring psychopathology and mood. The patients reported significantly higher levels of depression, anxiety, physical symptoms and cognitive failures than the controls. Similarly, they reported more negative affect at the time of testing.

The patients were slower on psychomotor tasks, showed increased visual sensitivity and impaired attention. Digit span and free recall were not impaired but retrieval from semantic memory and logical reasoning were slower. None of the performance differences between patients and controls could be attributed to differences in psychopathology. These results agree with recent findings from other laboratories, and it is now time to consider the nature of the neurological dysfunction underlying these effects.

 

Source: Smith AP, Behan PO, Bell W, Millar K, Bakheit M. Behavioural problems associated with the chronic fatigue syndrome. Br J Psychol. 1993 Aug;84 ( Pt 3):411-23. http://www.ncbi.nlm.nih.gov/pubmed/8401992