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Testosterone is the hormone responsible for the development of primary male sexual characteristics (sex organs), as well as secondary characteristics such as growth of body hair, increase in bone and muscle mass, and deepening of the voice. Testosterone promotes energy and a sense of well-being, and helps regulate the HPA axis. Women also produce testosterone, although at only a tenth of male levels. Low-dose testosterone is sometimes recommended for women at risk of osteoporosis.

As men age, their production of testosterone decreases. While this is a natural process, some men experience an abrupt or dramatic decline, sometimes brought about by disease processes. This abrupt decline has been dubbed "male menopause" (although gradual declines are often referred to as "male menopause" as well).

Zinc is necessary for the production of testosterone.

USES IN ME/CFS: As with other hormone deficiencies, low levels of testosterone are fairly common in ME/CFS patients. In men, this will be felt as a loss of libido, as well as a decrease in muscle strength, depression, anxiety, and bladder problems – all of which are symptoms common among ME/CFS patients of both sexes. As testosterone has such wide-ranging effects on the body, doctors should prescribe testosterone only after blood tests confirm low levels.

Men who have taken testosterone report an increase in energy. Some men experience "teenage problems" (acne).

John Bochenek, a male ME/CFS patient, reported remarkable results from taking testosterone under a physician's supervision. (His article, How I Recovered From ME/CFS, can be read on ProHealth.)


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