TREATMENT DATABASE

Bupropion (Wellbutrin) is an atypical antidepressant. Bupropion is believed to be both a norepinephrine and dopamine reuptake inhibitor.

USES IN ME/CFS: Physicians who specialize in the treatment of ME/CFS have prescribed bupropion when SSRIs have failed, and find it of benefit in improving energy and controlling mood. In some patients, bupropion does not produce the unpleasant side effects noted with other antidepressants. The drug may be taken alone or with other tricyclic antidepressants to improve sleep. Patients have reported increased energy, alleviation of depression, increase in concentration, and better sleep.

Bupropion is short acting, much like stimulants (e.g., Ritalin). Because bupropion raises dopamine, it is more habit-forming than other antidepressants. Side effects can be similar to those of SSRIs (jitters, anxiety, insomnia). Many patients find that bupropion, like CNS stimulants, provides only a short burst of energy, followed by a crash. Even patients who feel that bupropion has provided significant relief for cognitive symptoms have reported “cyclic thoughts” (like having a song stuck in your head). Patients have also reported headaches, nightmares, shakiness, rapid heartbeat, weight gain, and stomach irritation.

WARNING: Bupropion is not recommended for patients who are sensitive to stimulants, or who have a history of seizures or heart problems.

Treatment rating for Wellbutrin (bupropion)