TREATMENT DATABASE

Histame is a dietary supplement containing the enzyme, diamine oxidase (DAO). Diamine oxidase (also known as histaminase) is an enzyme found in large concentrations in the intestinal lining (mucosa) of all mammals. Its function is to break down histamine. Unlike antihistamines, Histame does not block histamine receptors, but acts directly on histamine itself.

In 2007 Maintz and Novak observed that people with low amounts of DAO can develop food sensitivities which symptomatically mimic food allergies (flushing, hypotension, diarrhea, headache, tachycardia, and itching). Although their symptoms match those of true allergies, these individuals do not test positive for IgE-mediated allergies. Low levels of circulating DAO prevent the breakdown of histamine in their intestines, causing allergic-type reactions, particularly to histamine-rich foods. Foods that are rich in histamine include all fermented and aged foods: cheese, alcohol, sauerkraut, canned fish (tuna, sardines), pizza, processed meats, as well as many fruits and chocolate. Nearly 100 drugs have been found to cause a decrease in DAO activity, including doxycycline, MAO inhibitors, cimetidine (Tagamet), and Verapamil (a calcium-channel blocker). DAO requires copper and Vitamins B2 and B6.

USES IN ME/CFS: Histamine intolerance is characteristic of ME/CFS patients. Aside from new allergies, many patients develop food sensitivities, as well as conditions such as migraines, rosacea and interstitial cystitis, which are provoked by tyrosine-rich foods. (Tyrosine is converted to tyramine, which is closely related to histamine.)

Treatment rating for Histame