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Diamox (acetazolamide) is a carbonic anhydrase inhibitor. It was introduced in 1953 as a diuretic. Because it reduces intraocular pressure, it is used to treat glaucoma. Diamox can also be used to treat edema, high-altitude sickness, and as an anticonvulsant.

Diamox blocks the action of carbonic anhydrase, an enzyme that helps form hydrogen and bicarbonate ions from carbon dioxide and water. It promotes excretion of sodium, potassium, water, and bicarbonate. By blocking carbonic anhydrase in the central nervous system and increasing carbon dioxide tension, Diamox also helps decrease abnormal neuronal discharge that may lead to convulsions. Because Diamox lowers blood pH, and encourages respiration, it has been prescribed to help with sleep apnea as well. Other uses include absence seizures, periodic paralysis and congestive heart failure.

USES IN ME/CFS: Diamox his been used to treat pressure-type headaches in ME/CFS patients. It can also help balance problems, and, over time, improve neurocognitive function, as it increases blood flow to the brain. Patients taking Diamox often report increased energy.


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