TREATMENT DATABASE

Nardil (phenalzine) is a monoamine oxidase inhibitor (MAOI). It is prescribed for depression and anxiety.

USES IN ME/CFS: MAOIs are used much less frequently than other antidepressants to treat ME/CFS. The side effects associated with phenalzine (Nardil ) and tranylcypromine (Parnate) can be severe. An additional drawback is the dietary restrictions that accompany MAOI use. Foods that contain the amino acid tyramine (aged cheese, yogurt, wine, avocado, among many others) must be avoided to prevent severe hypertensive crisis. Because these foods are so common, patients may find compliance difficult.

While some patients with ME/CFS have found MAOIs effective, others have reported agitation and insomnia. One patient believed an MAOI may have contributed to a prolonged relapse, producing even greater neurological and cognitive problems than she had experienced previously.

Treatment rating for Nardil (phenalzine)