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Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. It may decrease the risk of suicide in those over the age of 65.

Common side effects include trouble sleeping, loss of appetite, dry mouth, rash, and abnormal dreams. Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old, and an increased risk of bleeding. If stopped suddenly a withdrawal syndrome may occur with anxiety, dizziness, and changes in sensation.

USES IN ME/CFS: Because Prozac has stimulant properties it is used to treat fatigue. Many patients are sensitive to stimulants, so a low dose is normally prescribed.


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