TREATMENT DATABASE

Norpramin (desipramine) is a second-generation tricyclic antidepressant which primarily blocks the reuptake of norepinephrine and, to a lesser degree, serotonin.

USES IN ME/CFS: Tofranil is helpful in treating fatigue, pain, sleep disturbance, and anxiety. The main side effects are similar to those of other tricyclic antidepressants: dry mouth, constipation, and weight gain (due to increased appetite). Although the second-generation tricyclics are often prescribed for sleep, they often interfere with sleep onset. Other side effects experienced by people with ME/CFS include shakiness, agitation and nausea.

Treatment rating for Norpramin (desipramine)