Abstract:
As others have pointed out a variety of complicating factors with the PACE trial (e.g. changing outcome criteria), I will limit my remarks to issues that involve the composition of adaptive pacing therapy and issues involving patient selection. My key points are that the PACE trial investigators were not successful in designing and implementing a valid pacing intervention and patient selection ambiguity further compromised the study’s outcomes.
Source: Jason LA. The PACE trial missteps on pacing and patient selection. J Health Psychol. 2017 Aug;22(9):1141-1145. doi: 10.1177/1359105317695801. Epub 2017 Feb 1. https://www.ncbi.nlm.nih.gov/pubmed/28805518