TREATMENT DATABASE

Alpha ketoglutarate (AKG) is an ionic form of alpha ketoglutarate acid, an intermediate in the tricarboxylic cycle (Krebs cycle, or citric acid cycle). AKG fulfills a vital role in the metabolism and utilization of carbohydrates, proteins, and long-chain fatty acids. Its best known function is as a component of a number of energy-producing cycles at the cellular level. The first of these, the Krebs cycle, breaks down and transforms citric acid through a series of enzyme-controlled reactions to produce adenosine triphosphate (ATP), a crucial energy source for many cell processes. AKG, as an early intermediate in the Krebs cycle, forms the basis for all further transformations. It is also required for catabolism of many amino acids, another process that generates energy.

Another important function of AKG involves the formation of nonessential amino acids (amino acids that are biosynthesized in the body), notably glutamate and, through its action, proline, alanine, aspartic acid, and asparagine. AKG is also one of the most important transporters of cellular nitrogen, combining with nitrogen in the cell to prevent an overload of ammonia in the body.

USES IN ME/CFS: Because of AKG's essential role in energy production and carbohydrate metabolism, it may be useful as a general ME/CFS treatment. AKG is also beneficial for the intestines. AKG is converted in the intestines into glutamate, which regulates gastric emptying and provides an environment for healthy gut flora. AKG also prevents damage to the mucosal lining of the intestines by inhibiting oxidative stress.

Treatment rating for Alpha Ketoglutarate