Abstract:
As a result of the emergence and circulation of antigenically distinct SARS-CoV-2 variants, a number of variant-modified COVID-19 vaccines have been developed. Here we perform a meta-analysis of the available data on neutralisation titres from clinical studies comparing booster vaccination with either the current ancestral-based vaccines or variant-modified vaccines. We then use this to predict the relative efficacies of these booster vaccines under different scenarios.
Source: David S Khoury, Steffen S Docken, Kanta Subbarao, Stephen Kent, Miles Philip Davenport, Deborah Cromer. Predicting the efficacy of variant-modified COVID-19 vaccine boosters. medRxiv 2022.08.25.22279237; doi: https://doi.org/10.1101/2022.08.25.22279237 (Full article available as PDF file)