Is there a role for the adrenal glands in long COVID?

Introduction:

After the acute phase of SARS-CoV-2 infection, roughly 20% of patients report one or more complications, which are particularly apparent during mental or physical stress. These complications include extreme chronic fatigue, shortness of breath, sleep abnormalities, headache, brain fog, joint pains, nausea, cough and abdominal pain. When symptoms persist for more than four weeks after initial infection and cannot be attributed to other known diseases, they are described as long COVID¹. When comparing the clinical presentation of long COVID and chronic adrenal insufficiency, overlap between the conditions can be seen, suggesting that long COVID might be related to some form of adrenal dysfunction². Here we discuss the role of the adrenal glands in long COVID.

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Source: Kanczkowski W, Beuschlein F, Bornstein SR. Is there a role for the adrenal glands in long COVID? Nat Rev Endocrinol. 2022 May 30:1–2. doi: 10.1038/s41574-022-00700-8. Epub ahead of print. PMID: 35637413; PMCID: PMC9150041. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150041/ (Full text)