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The review of the differences and similarities in the different case definitions for myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) by Lim and Son [1] deserves appreciation. Based on their analysis the authors acknowledge the “distinct view of ME and CFS” [2] and recognize four categories of case definitions: ME, ME/CFS, CFS [3] and Systemic Exertion Intolerance Disorder (SEID) [4].
Indeed these labels reflect very different case definitions [5]. According to Lim and Son [1] the first category comprises two ‘ME’ case definitions: ME (Ramsay) [6] and ME according to the International Case Criteria (ME-ICC) [7]. However as can be deduced from Table 2 [1], ME [6] and ME-ICC [7] are two distinct clinical entities [8].
Source: Twisk FNM. ME (Ramsay) and ME-International Case Criteria (ME-ICC): two distinct clinical entities. J Transl Med. 2020 Nov 25;18(1):447. doi: 10.1186/s12967-020-02617-0. PMID: 33239008. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02617-0 (Full text)