Current status of xenotropic murine leukemia virus-related retrovirus in chronic fatigue syndrome and prostate cancer: reach for a scorecard, not a prescription pad

Xenotropic murine leukemia virus-related retrovirus (XMRV) is a newly discovered member of the gammaretrovirus genus of retroviruses, which has been recently associated with 2 human disorders, prostate cancer and chronic fatigue syndrome [1]. Since it was first reported in 2006, XMRV has been intensely investigated, but no clear picture of prevalence, geographic distribution, or disease association has emerged. In this issue of the Journal, 3 studies shed new light on the presence of XMRV in human populations.

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Detection of xenotropic murine leukemia virus-related virus in normal and tumor tissue of patients from the southern United States with prostate cancer is dependent on specific polymerase chain reaction conditions. [J Infect Dis. 2010]

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections. [J Infect Dis. 2010]

Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions. [J Infect Dis. 2010]

 

Source: Kearney M, Maldarelli F. Current status of xenotropic murine leukemia virus-related retrovirus in chronic fatigue syndrome and prostate cancer: reach for a scorecard, not a prescription pad. J Infect Dis. 2010 Nov 15;202(10):1463-6. doi: 10.1086/657169. Epub 2010 Oct 11. http://jid.oxfordjournals.org/content/202/10/1463.long (Full article)