Abstract:
The effect of live oral polio virus vaccination on chronic fatigue syndrome (CFS) patients was examined in a double-blind study. CFS patients were allocated randomly to placebo (N = 7) or vaccine (N = 7) conditions. All controls subjects received the vaccine (9).
Vaccine administration was not associated with clinical exacerbation of CFS. However, objective responses to the vaccine revealed differences between patients and controls: increased poliovirus isolation, earlier peak proliferative responses, lower T-cell subsets on certain days post vaccination and a trend for reduced gamma-interferon in the CFS-vaccine group.
Polio vaccination was not found to be clinically contraindicated in CFS patients, however, there was evidence of altered immune reactivity and virus clearance.
Source: Vedhara K, Llewelyn MB, Fox JD, Jones M, Jones R, Clements GB, Wang EC, Smith AP, Borysiewicz LK. Consequences of live poliovirus vaccine administration in chronic fatigue syndrome. J Neuroimmunol. 1997 May;75(1-2):183-95. http://www.ncbi.nlm.nih.gov/pubmed/9143253